Mechanochemically synthesized mesoporous alumina: a smart new-generation sorbent for preparation of chromatographic 188W/188Re generator

Abstract In an effort towards affordable availability of chromatographic 188 W/ Re generators for widespread clinical use, we report the mechanochemical synthesis mesoporous alumina as advanced sorbent material preparation generator. The synthesized exhibits remarkably high sorption capacity (550 ± 12 mg W/g), which is adequate clinical-scale using low specific activity (LSA) W produced in medium flux research reactors. Sorption follows Freundlich adsorption isotherm and pseudo second order kinetics, indicating that process chemisorption. A (~ 14.0 GBq) generator was developed its performance evaluated over a period 6 months. Rhenium-188 could be consistently obtained from with yield (> 80%) it met all requirements use. present strategy expected to increase scope separation chemistry availing clinical-grade benefit millions cancer patients world over. Graphic abstract